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Dr Sam Stewart and Pharmacologist, Gus Cochrane, spend their spare moments chasing venomous creatures to discover the secrets of venom. When the mainland University Hospital wants more venom for research, Sam pleads with her ex-husband (and boss), Andrew, to send her a new doctor to assist her in the running of her remote Hope Island Clinic. The new Doctor Rick D’Alessandro - an arrogant party boy who thought he was going to a medical centre at a 5-star island resort - arrives during a medical emergency when a scuba diver surfaces too rapidly and gets the bends. Together with Toby McGrath, the local dive-boat operator, Sam and Rick work together on a dangerous recompression procedure to save the diver from potential brain damage – or death.