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All over the world, many species of large mammals, such as mammoths, cave bears and giant sloths, died out at the end of the last Ice Age. Did humans cause a mass extinction, or did these giants fall victim to the rise in temperature? This documentary follows palaeontologist Dick Mol on the hunt for clues to the extinction of the Ice Age giants.

Dick Mol and his colleagues discover that these mammals had already been challenged by rising temperatures. So, climate change and the arrival of mankind might have been the deadly combination for the giants, who were not able to adapt to the changing environment in time. From ancient bone hoards to footprints in gypsum dune fields and permafrost tree remains, the researchers find significant traces of Ice Age hunters — bringing them closer to solving a mystery that is 12,000 years old.