Gynecologist Dr. Bernd Rogge, internal medicine specialist Dr. Stefan Junginger and pediatrician Dr. Daniel Holbein come together to take over the practice of old Walter Leibrecht, who is retiring. Bernd is a yuppie, occasionally brusque, and he leads a somewhat pretentious lifestyle, but is basically a good guy. Stefan is an obstinate doctor, but sometimes slightly insecure. Daniel, a young idealist, enters into a relationship with doctor Beate Chevalier. The practice’s team is rounded off by two assistants, Rüdiger Kissling and Renate Paulus.

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